Prof. Dr. rer. nat. Katrin Marcus

Date of Birth: 21 November 1972
Nationality: German


Education:

Doctoral thesis at the Faculty of Chemistry and Biochemistry „Analysis of the phosphoproteome of human thrombin-stimulated platelets“, Proteinstructure laboratory, Prof. Dr. H.E. Meyer, Ruhr-Universität Bochum, Germany


Studies of biochemistry (Faculty of Chemistry and Biochemistry), Ruhr-Universität Bochum, Germany


Vocational education; Certified Biological-technical Assistant at the “Rheinische Akademie e.V.”, Cologne, Germany


Professional Experience:

Director of the “Medizinische Proteom-Center Funktionelle Proteomik”, Ruhr-Universität Bochum


Appointment as a Full Professor, Functional Proteomics, Medical Faculty, Ruhr-Universität Bochum


Offer of a W2-professorship, University of Regensburg, Med. Faculty
Offer of a professorship/tenured academic staff, University of Antwerp, Dep. of Chemistry, Faculty of Science


Juniorprofessor for Proteomics at the Medizinische Proteom-Center (independent position), Ruhr-Universität Bochum, Germany (extended for 3 years due to positive evaluation in July 2006)


Group leader of the “Brain Proteomics”-group at the Medizinische Proteom-Center, Ruhr-Universität Bochum, Germany


Project leader of several projects (funded by DFG, BMBF, EU etc.)
Personnel responsibility for Post-Docs, PhD students and Technical Assistants


Teaching:

Supervision of PhD students and graduates


Organisation and implementation of several lectures/seminars/practical courses at the Medical Faculty, Faculty of Biology and Faculty of Chemistry, Ruhr-University Bochum


Lectureships

Lectureship at the University of applied science Bonn-Rhein-Sieg, practical course and seminar „Instrumental Analytics"


Research Interests:

Functional proteomics, protein chemistry, mass spectrometry, post-translational modifications, method development, neurodegenerative disorders, neuromuscular disorders

Awards/Grants/Honors:

HUPO Young Investigator Award


Lore Agnes Award


Memberships:

DGPF (German Society for Proteome Research)
EuPA (European Proteomics Association)
GBM (Society for Biochemistry and Molecular Biology)
FEBS (Federation of European Biochemical Societies)
DPG (German Parkinson Association)
DHV (German Academy Association)
Research Department Protein (Ruhr-University Bochum)
International Graduate School of Neurosciences (Ruhr-University Bochum)
International Graduate School of Biosciences (Ruhr-University Bochum)

Organisation of (Scientific) Events:

Person responsible and organization of the program “m2[at]RUB” - Mentoring for female scientists at the Medical Faculty, Ruhr-University Bochum (2008-2013 in Bochum, Germany)
Organisation and management of eight European Summer schools „Proteomic Basics“, funded by the Volkswagenstiftung and FEBS (2007-2016 in Brixen, Brixen, South Tyrol, Italy)
Organisation and management of three Summer schools „Proteomic Basics“, funded by the BMBF and the DGPF (German Association for Proteome Research) (2004 in Opatija, Croatia; 2005 and 2006 in Brixen, South Tyrol, Italy)
Co-organisation of a PENS Summer school “Neuroproteomics in animal models for neurodegenerative disorders” (June 2010 in Smolenice, Slovakia)
Co-organisation of three “DIGE” workshops (2006, 2007, 2010 in Bochum, Germany)
Co-organisation of a workshop "Computational Proteomics" (March 2008, Schloss Dagstuhl)
Organisation and management of two GBM (Association for Biochemistry and Molecular Biology) training courses, „Fundamentals of nanoLC-MS/MS“ (2002 in Bochum, Germany)

Other Professional Activities:

Steering Committee member of the HUPO Brain Proteome Project (since 2015)
Deputy member of the faculty council (since 2015)
Editorial Board Member “Journal of Proteomics” (since 2011) and „Frontiers in Molecular Neuroscience“ (since 2017)
Reviewer in the BMBF funding program “KMUinnovativ” (since 2011)
General Secretary of the HUPO Brain Proteome Project (since 2009)
Equal opportunities officer at the Medical Faculty, Ruhr-University Bochum (since 2008)
Mentor in the program “m2[at]RUB” - Mentoring for female scientists at the Medical Faculty, Ruhr-University Bochum (since 2008)
Mentor in the program “Tandem plus MED” - Mentoring for female scientists at the Medical Faculty, RWTH Aachen (since 2009-2010)
Invited Guest Editor „Quantitative Methods in Proteomics“, Methods in Molecular Biology, Humana Press, 2012
Invited Guest Editor, Special Issue “Neuroproteomics”, Expert reviews for Proteomics, Future Drugs Ltd, 2007
Invited Editor, Special Issue “Proteomics/Genomics”, Journal of Neural Transmission, Springer, 2005
Invited Editor, „Proteomics in Drug Research“, Methods and Principles in Medicinal Chemistry, Wiley-VCH, 2004
Ad hoc reviewer for several journals (Proteomics, BBA, J Prot Res, JNT, FEBS, J Proteomics etc.)
Chair of the working committee “Membrane proteins” of the German Proteomics Society (DGPF) (2008-2012)
Co-chair of the “Technology Platforms & Standardization Committee”, HUPO Human Brain Proteome Project (2005-2009)

Publications:

Original articles 

Current Projects and funding:

Since 2004 several individual as well as network grants from EU, BMBF (Federal Ministry of Education and Research), DFG (German Research Association), AFI (Alzheimer Research Initiative), Volkswagen Stiftung

Current research grants held:
MaIK Massenspektrometrie basierte Identifizierung von Körperflüssigkeiten für forensische Zwecke
Principal Investigator
Landeskriminalamt, Northrhine Westfalia
Total Sum (own part) 206.791 €

OsteoSys: Osteoporose – eine Volkserkrankung im Kontext von kardiovaskulärer Komplikationen und chronischer Inflammation: systemmedizinischer Ansatz zur personalisierten Therapie
Principal Investigator
Ministry of Education, Science and Research, Northrhine Westfalia
Total Sum (own part) 260.379 €

NISCI – Antibodies against Nogo-­‐A to enhance regeneration and functional recovery after acute spinal cord injury a multicenter European clinical proof of concept trial
Principal Investigator
EU
Total Sum (own part) 295.000 €

Role of Cavβ2 splice variants in the association of L-type voltage-gated calcium channels to specific calcium signaling pathways in different subcellular microdomains of cardiac myocytes
Principal Investigator
DFG
Total Sum (own part) 82.100 €

ValiBio – Validierung Marker-freier Imaging-Verfahren und neu identifizierter Biomarker unter Nutzung des PURE Konsortiums
Principal Investigator
Ministry of Education, Science and Research, Northrhine Westfalia
Total Sum (own part) 1.135.000 €

Isolierung von spezifischen Neuronenpopulationen und Gliazellen aus humaner Substantia nigra
Principal Investigator
Ministry of Education and Research, Germany
Total Sum (own part) 154.875 €

German Network for Bioinformatics Infrastructure, deNBI
Ministry of Education and Research, Germany
Total Sum (own part) 2.097.482 €

SFB 642: ATP- und GTP-abhängige Membranprozesse
Principal Investigator
DFG
Total Sum (own part) 350.000 €

Subcellular proteome analysis of neuromelanin-granules and Lewy-bodies of healthy controls and Parkinson’s-diseased subjects
Principal Investigator
Verein zur Durchführung Neurowissenschaftlicher Tagungen e.V.
Total Sum 34.500 €

FOR1228 - Molecular Pathogenesis of Myofibrillar Myopathies
Leader of subproject
DFG (German Research Foundation)

Establishment of laser microdissection combined with mass spectrometry in patients with sporadic inclusion body myositis (sIBM) to decipher the protein composition of rimmed vacuoles
Co-Principal Investigator
Medical Faculty at RUB (FoRUM)
Total Sum 47.500 €

„BIOMARKAPD: Harmonisation and Standardization for Biomarkers in Alzheimer's and Parkinson's Disease”
Principal Investigator
EU/BMBF
Total Sum 64.383 €

Supplement financing -„BIOMARKAPD- Harmonisation and Standardization for Biomarkers in Alzheimer's and Parkinson's Disease”
Principal Investigator
Medical Faculty at RUB (FoRUM)
Total Sum 53.653 €

Tracking the function of the E3 ubiquitin ligase parkin in the cellular stress response
Principal Investigator
DFG (German Research Foundation)
Total Sum 174.950 €