Prof. Dr. rer. nat. Katrin Marcus

Date of Birth: 21 November 1972
Nationality: German


Education:

Doctoral thesis at the Faculty of Chemistry and Biochemistry „Analysis of the phosphoproteome of human thrombin-stimulated platelets“, Proteinstructure laboratory, Prof. Dr. H.E. Meyer, Ruhr-Universität Bochum, Germany


Studies of biochemistry (Faculty of Chemistry and Biochemistry), Ruhr- Universität Bochum, Germany


Vocational education; Certified Biological-technical Assistant at the “Rheinische Akademie e.V.”, Cologne, Germany


Professional Experience:

Director of the “Medizinische Proteom-Center Funktionelle Proteomik”, Ruhr-Universität Bochum


Appointment as a Full Professor, Functional Proteomics, Medical Faculty, Ruhr-Universität Bochum


Offer of a W2-professorship, University of Regensburg, Med. Faculty
Offer of a professorship/tenured academic staff, University of Antwerp, Dep. of Chemistry, Faculty of Science


Juniorprofessor for Proteomics at the Medizinische Proteom-Center (independent position), Ruhr-Universität Bochum, Germany (extended for 3 years due to positive evaluation in July 2006)


Group leader of the “Brain Proteomics”-group at the Medizinische Proteom-Center, Ruhr-Universität Bochum, Germany


Project leader of several projects (funded by DFG, BMBF, EU etc.)
Personnel responsibility for Post-Docs, PhD students and Technical Assistants


Teaching:

Supervision of PhD students and graduates


Organisation and implementation of several lectures/seminars/practical courses at the Medical Faculty, Faculty of Biology and Faculty of Chemistry, Ruhr-University Bochum


Lectureships

Lectureship at the University of applied science Bonn-Rhein-Sieg, practical course and seminar „Instrumental Analytics


Research Interests:

Functional proteomics, protein chemistry, mass spectrometry, post-translational modifications, method development, neurodegenerative disorders, neuromuscular disorders

Awards/Grants/Honors

HUPO Young Investigator Award


Lore Agnes Award


Memberships:

DGPF (German Society for Proteome Research)
EuPA (European Proteomics Association)
GBM (Society for Biochemistry and Molecular Biology)
FEBS (Federation of European Biochemical Societies)
DPG (German Parkinson Association)
DHV (German Academy Association)
Research Department Protein (Ruhr-University Bochum)
International Graduate School of Neurosciences (Ruhr-University Bochum)
International Graduate School of Biosciences (Ruhr-University Bochum)

Organisation of (Scientific) Events:

Person responsible and organization of the program “m2[at]RUB” - Mentoring for female scientists at the Medical Faculty, Ruhr-University Bochum (2008-2013 in Bochum, Germany)
Organisation and management of seven European Summer schools „Proteomic Basics“, funded by the Volkswagenstiftung and FEBS (2007-2014 in Brixen, Brixen, South Tyrol, Italy)
Organisation and management of three Summer schools „Proteomic Basics“, funded by the BMBF and the DGPF (German Association for Proteome Research) (2004 in Opatija, Croatia; 2005 and 2006 in Brixen, South Tyrol, Italy)
Co-organisation of a PENS Summer school “Neuroproteomics in animal models for neurodegenerative disorders” (June 2010 in Smolenice, Slovakia)
Co-organisation of three “DIGE” workshops (2006, 2007, 2010 in Bochum, Germany)
Co-organisation of a workshop "Computational Proteomics" (March 2008, Schloß Dagstuhl)
Organisation and management of two GBM (Association for Biochemistry and Molecular Biology) training courses, „Fundamentals of nanoLC-MS/MS“ (2002 in Bochum, Germany)

Other Professional Activities:

Reviewer in the BMBF funding program “KMUinnovativ”
General Secretary of the HUPO Brain Proteome Project (since 2009)
Equal opportunities officer at the Medical Faculty, Ruhr-University Bochum (since 2008)
Mentor in the program “m2[at]RUB” - Mentoring for female scientists at the Medical Faculty, Ruhr-University Bochum (since 2008)
Mentor in the program “Tandem plus MED” - Mentoring for female scientists at the Medical Faculty, RWTH Aachen (since 2009-2010)
Invited Guest Editor, „Quantitative Methods in Proteomics“, Methods in Molecular Biology, Humana Press, 2012
Invited Guest Editor, Special Issue “Neuroproteomics”, Expert reviews for Proteomics, Future Drugs Ltd, 2007
Invited Editor, Special Issue “Proteomics/Genomics”, Journal of Neural Transmission, Springer, 2005
Invited Editor, „Proteomics in Drug Research“, Methods and Principles in Medicinal Chemistry, Wiley-VCH, 2004
Ad hoc reviewer for several journals (Proteomics, BBA, J Prot Res, JNT, FEBS, J Proteomics etc.)
Chair of the working committee “Membrane proteins” of the German Proteomics Society (DGPF) (2008-2012)
Co-chair of the “Technology Platforms & Standardization Committee”, HUPO Human Brain Proteome Project (2005-2009)

Publications:

Original articles 

Book chapters

1. Proteome Analysis with classical 2D PAGE, May C., Brosseron F., Pfeiffer K., Meyer H.E., Marcus K., Methods Mol Biol., In: Quantitative Methods in Proteomics, Humana Press, Editor: Katrin Marcus, 2012, 893, 37-46
2. Differential Proteome Analysis using 2D-DIGE, May C., Brosseron F., Chartowski P., Meyer H.E., Marcus K., Methods Mol Biol., In: Quantitative Methods in Proteomics, Humana Press, Editor: Katrin Marcus, 2012, 893, 75-82
3. Discovering the phosphoproteome of the hydrophobic cytochrome c oxidase membrane protein complex, Helling S., Hüttemann M., Kadenbach B., Ramzan R., Vogt S., Marcus K., Methods Mol Biol., In: Quantitative Methods in Proteomics, Humana Press, Editor: Katrin Marcus, 2012, 893, 345-358
4. Instruments and Methods in Proteomics, May C., Brosseron F., Chartowski P., Schumbrutzki C., Schoenebeck B., Marcus K., Methods Mol Biol., In: Data Mining in Proteomics, Humana Press, Editors: Michael Hamacher, Christian Stephan, Martin Eisenacher, 2011, 696, 3-26
5. Inter-lab proteomics: data mining in collaborative projects on the basis of the HUPO brain proteome project's pilot studies, Hamacher M., Gröttrup B., Eisenacher M., Marcus K., Park Y.M., Meyer H.E., Kwon K.H., Stephan C., Methods Mol Biol., In: Data Mining in Proteomics, Humana Press, Editors: Michael Hamacher, Christian Stephan, Martin Eisenacher, 2011, 696, 235-246
6. High-resolution two-dimensional gel electrophoresis (2-DE) – different methods and applications, Marcus K., Joppich C., May C., Pfeiffer K., Sitek B., Meyer H.E., Stuehler K., Methods Mol Biol., Humana Press, Two Dimensional Electrophoresis Protocols, Editor: David Sheehan, Chapter 14, 2009, 519, 221-240
7. Common Methods in Proteomics, Urlaub H., Grønborg M., Richter F., Veenstra T.D., Müller T., Tribl F., Meyer H.E., Marcus K., Wiley-VCH, Weinheim, Proteomics of the nervous system, Editors: Nothwang, Pfeiffer, Chapter 2, 2008, 19-34
8. Proteomics of Neurodegenerative Disorders, Müller T., Tribl F., Hamacher M., van Hall A., Meyer H.E., Marcus K., Wiley-VCH, Weinheim, Proteomics of the nervous system, Editors: Nothwang, Pfeiffer, Chapter 12, 2008, 207-225
9. NanoLC-MS/MS in Proteomics, Schäfer H., Lohaus C., Meyer H.E., Marcus K., Wiley-VCH, Weinheim, HPLC - made to measure, Editor: Stavros Kromidas, english version, Chapter 5.1, 2006, 627-642
10. NanoLC-MS/MS in der Proteomforschung, Schäfer H., Lohaus C., Meyer H.E., Marcus K., HPLC – richtig optimiert, Wiley-VCH, Weinheim, Editor: Stavros Kromidas, Chapter 5.1, 2006, 653-668
11. Analytik posttranslationaler Modifikationen – Phosphorylierung und Acetylierung von Proteinen, Dormeyer W., Schulenborg T., Schnölzer M., Meyer H.E., Marcus K., Bioanalytik, Elsevier, Heidelberg, Editors: F. Lottspeich & J. W. Engels, Chapter 24, 2006, 617-634
12. Differential Phosphoproteome Analysis in Medical Research, Butt E., Marcus K., Proteomics in Drug Research, Methods and Principles in Medicinal Chemistry (Band 28), Wiley VCH, Weinheim, Editoren: M. Hamacher, K. Marcus et al., Section III, Chapter 11, 2006, 209-221
13. Proteomics – Application to the Brain, International Review of Neurobiology, Marcus K., Schmidt O., Schaefer H., Hamacher M., van Hall A., Meyer H.E., Elsevier Inc., Volume 61, Human Brain Proteome, Editor: Lisa A. Neuhold, Section V, Chapter 11, Overview of the Neuroproteome, 2004
14. Two-dimensional polyacrylamide gel electrophoresis for platelet proteomics, Marcus K., Meyer H.E., Platelets and Megakarycytes: a volume of Methods in Molecular Biology Series, Humana Press Inc., Volume 2, Perspectives and Techniques, Editors: J.M. Gibbins & M.P. Mahaut-Smith, Chapter 26, 2004, 421-433
15. Phosphoproteomics of human platelets, Marcus K., Meyer H.E., Platelet Function: Assessment, Diagnosis and Treatment: a volume of Contemporary Cardiology Series, Humana Press Inc., Editors: M. Quinn & D. Fitzgerald, Chapter 7, 2005, 175-198

Reviews

1. Proteomics in neurodegenerative diseases: Methods for obtaining a closer look at the neuronal proteome, Plum S., Steinbach S., Abel L., Marcus K., Helling S., May C., Proteomics Clin Appl., in press
2. Regulation of mitochondrial respiration and apoptosis through cell signaling: cytochrome c oxidase and cytochrome c in ischemia/reperfusion injury and inflammation, Hüttemann M., Helling S., Sanderson T.H., Sinkler C., Samavati L., Mahapatra G., Varughese A., Lu G., Liu J., Grossman L.I., Doan J.W., Marcus K., Lee I., BBA Bioenergetics 2012, 1817(4), 598-609
3. Quantification of α-synuclein in cerebrospinal fluid as a biomarker candidate: review of the literature and considerations for future studies. Mollenhauer B., El-Agnaf O.M,. Marcus K., Trenkwalder C., Schlossmacher M.G., Biomark Med., 2010, 4(5), 683-699
4. Quantitative analysis of highly homologous proteins: The challenge of assaying the "cyp-ome" by mass spectrometry, Langenfeld E., Meyer H.E., Marcus K., Anal Bioanal Chem, 2008, 392 (6), 1123-1134
5. The amyloid precursor protein intracellular domain (AICD) as modulator of gene expression, apoptosis, and cytoskeletal dynamics-Relevance for Alzheimer's disease, Müller T., Meyer H.E., Egensperger R., Marcus K., Prog Neurobiol., 2008 (4), 393-406 (Top-10 most cited articles: 2008-2010)
6. Multidimensional advancement of neuroproteomics, Veenstra T.D., Marcus K., Expert Rev Proteomics. 2008 (2), 149-151
7. Analysis of organelles within the nervous system: impact on brain and organelle functions, Tribl F., Meyer H.E., Marcus K., Expert Rev Proteomics. 2008 (2), 333-351
8. Maintaining standardization: an update of the HUPO Brain Proteome Project, Hamacher M., Stephan C., Eisenacher M., Hardt T., Marcus K., Meyer H.E., Expert Rev Proteomics, 2008 (5(2)), 165-173
9. New access to Alzheimer's and other neurodegenerative diseases, Hamacher M, Meyer HE, Marcus K., Expert Rev Proteomics, 2007, 4(5), 591-594
10. Proteomics in neurodegeneration – Disease Driven Approaches/ Proteomics – the matured tool of brain research?!, Schulenborg T., Schmidt O., van Hall A., Meyer H.E., Hamacher M., Marcus K., J Neural Transm, 2006 (113(8)), 1055-1073
11. The HUPO Brain Proteome Project – No need to hurry?, Hamacher M., Marcus K., van Hall A., Meyer H.E., Stephan C., J Neural Transm, 2006 (113(8)), 963-967
12. Proteomics of the human brain: sub-proteomes might hold the key to handle brain complexity, Tribl F., Marcus K., Bringmann G., Meyer H.E., Gerlach M., Riederer R., J Neural Transm, 2006 (113(8)), 1041-1054
13. How proteomics reveals potential biomarkers in brain diseases, Schmidt O., Schulenborg T., Meyer H.E., Marcus K., Hamacher M., Expert Rev. Proteomics, 2005 (2), 901-913

Non Peer-Reviewed Manuscripts

1. Frontiers in neurodegeneration--new insights and prospects--20th HUPO BPP Workshop: 15 September 2013, Yokohama, Japan., Schrötter A., El Magraoui F., Gröttrup B., Heinsen H., Marcus K., Meyer H.E., Park Y.M., Grinberg L.T., Proteomics 2013, 14(11), 1305-1307
2. Early diagnosis of neurodegenerative diseases - the long awaited Holy Grail and bottleneck of modern brain research - 19th HUPO BPP workshop: May 22-24, 2013, Dortmund, Germany. Schrötter A., Magraoui F.E., Gröttrup B., Wiltfang J., Heinsen H., Marcus K., Meyer H.E., Grinberg L.T., Park Y.M., Proteomics. 2013, 13(20), 2938-2941
3. Challenges in Modern Biomarker Discovery - 17(th) HUPO BPP Workshop: May 24-25, 2012, Sao Paulo, Brazil. Gröttrup B., Esselmann H., May C., Schrötter A., Woitalla D., Heinsen H., Marcus K., Wiltfang J., Meyer H.E., Grinberg L.T., Park Y.M., Proteomics, 2013 13(2), 210-216
4. Mentoring an der Medizinischen Fakultät der Ruhr-Universität Bochum – mQuadrat[at]RUB, Marcus K., Lutz M., Rudack H., Journal Netzwerk Frauen- und Geschlechterforschung NRW, 2012, 30, 57- 59
5. Translational proteomics in neurodegenerative diseases--16th HUPO BPP workshop September 5, 2011 Geneva, Switzerland, Gröttrup B., Böckmann M., Stephan C., Marcus K., Grinberg L.T., Meyer H.E., Park Y.M., Proteomics, 2012, 12(3), 356-358
6. Clinical aspects of neurodegenerative diseases - 15th HUPO BPP Workshop April 8-9, 2011, Bochum, Germany, Gröttrup B., Böckmann M., Marcus K., Wiltfang J., Grinberg L.T., Meyer H.E., Park Y.M., Proteomics, 2011, 11(22), 4279-4283
7. Creating a human brain proteome atlas--14th HUPO BPP workshop September 20-21, 2010, Sydney, Australia, Gröttrup B., Marcus K., Grinberg L.T., Lee S.K., Meyer H.E., Park Y.M., Proteomics, 2011, 11(16), 3269-3272
8. Creating a Human Brain Proteome Atlas - 13th HUPO BPP Workshop March 30-31, 2010, Ochang, Korea, Gröttrup B., Stephan C., Marcus K., Grinberg L.T., Wiltfang J., Lee S.K., Kim Y.H, Meyer H.E., Park Y.M., Proteomics, 2011, 11(14), 2759-2762
9. Proteomic basics - Quantification and post-translational modifications of proteins: The 3rd European summer school in Kloster Neustift., Marcus K., Schmidt C., Urlaub H., J. Proteomics. 2010, 73 (4), 697-700
10. Human Brain Proteome Project - 12th HUPO BPP Workshop. 26 September 2009, Toronto, Canada, Gröttrup B., Eisenacher M., Stephan C., Marcus K., Lee B., Meyer H.E., Park Y.M., Proteomics, 2010, 10(11), 2071-2073
11. Mass spectrometry-based assay for absolute quantification of cytochromes P450 in human liver, Schnabel A., Langenfeld E., Serschnitzki B., Vacun G., Reuss M., Zanger U.M., Meyer H.E., Marcus K., Proceedings of the 16th International Conference on Cytochrome P450, 2009, 161-164
12. AICD – Wegbereiter des Morbus Alzheimer?, Müller T., Schrötter, A., Marcus K., Bio-Spektrum, 2009, 04.09, 374-376
13. ‘Proteomic Basics – Sample Preparation and Separation’: The first European Summer School in Kloster Neustift (near Bressanone/Brixen, South Tyrol) Italy 12–18 August 2007, Marcus K., Kühn-Hölsken E., Schmidt C., Schulenborg T., Urlaub H., Proteomics, 2008, 8(2), 230-233
14. HUPO Brain Proteome Project: toward a code of conduct, Hamacher M., Marcus K., Stephan C., Klose J., Park Y.M., Meyer H.E., Mol Cell Proteomics, 2008, 7(2), 457
15. Quantitativer Nachweis von Leberenzymen des Arzneimittel-Abbaus, Schnabel A., Langenfeld E., Redlich G., Zanger U.M., Marcus K., Laborwelt, 2008, 4, 31-33
16. The HUPO Brain Proteome project wish list--summary of the 9(th) HUPO BPP Workshop 9-10 January 2008, Barbados, Hamacher M., Eisenacher M., Tribl F., Stephan C., Marcus K., Hardt T., Wiltfang J., Martens L., Desiderio D., Gutstein H., Park Y.M., Meyer H.E., Proteomics, 2008 8(11), 2160-2164
17. Applications in brain proteomics: 8(th) HUPO Brain Proteome Project Workshop 7 October 2007 Seoul, Korea, Hamacher M., Stephan C., Hardt T., Eisenacher M., Henkel A., Wiltfang J., Jimenez C.R., Park Y.M., Marcus K., Meyer H.E., Proteomics, 2008, 8(9), 1750-1753
18. Brain Research: Will History Repeat Itself in Proteomics?, Hamacher M., Stephan C., Marcus K., Meyer H.E., J. Proteome Res., 2007, 6(12), 4539
19. Die komplexe Welt der Zuckerreste - Glykoproteomics im östlichen Ruhrgebiet Klare N., Hamacher M., Marcus K., Grünewald P., van Hall A.,Meyer H.E., BioTec., 2007 (3), 12-13
20. Zucker nutzbar machen – moderne Proteomforschung im Fokus, Klare N., Grünewald P., Marcus K., Meyer H.E., van Hall A., Hamacher M., Laborwelt, 2007, 2, 28-29
21. Proteomics for everyday use: activities of the HUPO Brain Proteome Project during the 5th HUPO World Congress Hamacher M., Stephan C., Eisenacher M., van Hall A., Marcus K., Martens L., Park Y.M., Gutstein H.B., Herberg F., Meyer H.E., Proteomics, 2007, 7(7), 1012-1015
22. Proteomik, Marcus K., Technologieführer – Grundlagen, Anwendungen, Trends, Springer-Verlag, Hrsg. Hans-Joerg Bullinger, Chapter 4, 200-203
23. Membranproteine und differenzielle Proteomanalyse: Fortwährende Herausforderungen, neue Technologien, Langenfeld E., Redlich G., Meyer H.E., Marcus K., Biospektrum, 2006 (5), 508-509
24. Preface - Special Issue: Proteomics in neurodegeneration - from samples to target proteins and biomarkers, Meyer H.E., Marcus K., J Neural Transm, 2006 (113(8)), 959-961
25. Bridging Proteomics and Medical Science - the 5th HUPO Brain Proteome Workshop in Dublin, Ireland, Hamacher M., Stephan C., Palacios Bustamante N., van Hall A., Marcus K., Reidegeld K.A., Gantly A., Pennington S.R., Dunn M.J., Meyer H.E., Proteomics, 2006, 6(9), 2634-2637
26. The HUPO Brain Proteome Project Jamboree: Centralised summary of the pilot studies, Hamacher M., Stephan C., Bluggel M., Chamrad D., Korting G., Martens L., Muller M., Hermjakob H., Parkinson D., Dowsey A., Reidegeld K.A., Marcus K., Dunn M.J., Meyer H.E., Apweiler R., Proteomics, 2006, 6(6), 1719-1721
27. 4(th) HUPO Brain Proteome Project Workshop in Munich, Hamacher M., Stephan C., Palacios Bustamante N., van Hall A., Marcus K., Meyer H.E., Germany, Proteomics, 2006, 6(1), 14-15
28. 5th HUPO BPP Bioinformatics Meeting at the European Bioinformatics Institute in Hinxton, UK - Setting the Analysis Frame, Stephan C., Hamacher M., Bluggel M., Korting G., Chamrad D., Scheer C., Marcus K., Reidegeld K.A., Lohaus C., Schafer H. Martens L., Jones P., Muller M., Auyeung K., Taylor C., Binz P.A., Thiele H., Parkinson D., Meyer H.E., Apweiler R., Proteomics, 2005, 5(14), 3560-3562
29. HUPO BPP Workshop on Mouse Models for Neurodegeneration - Choosing the right models, Hamacher M., Marcus K., Stephan C., van Hall A., Meyer H.E., Proteomics, 2005, 5(14), 3558-3559
30. Does understanding the brain need proteomics and does understanding proteomics need brains?--Second HUPO HBPP Workshop hosted in Paris, Hamacher M., Klose J., Rossier J., Marcus K., Meyer H.E., Proteomics, 2004 (7), 1932-1934
31. LC-ESI-MALDI: Integrierte Akquisition komplementärer MS-MS-Informationen für die Proteomanalytik, Hahner S., Jabs W., Klinski M., Lubeck M., Marcus K., Meyer H.E., Schulenborg T., Suckau D., Biospektrum, 2004 (3), 323
32. Das HUPO Brain Proteome Projekt – Der Kampf gegen neurodegenerative Erkrankungen, Meyer H.E., Marcus K., van Hall A., Hamacher M., Going Public “Biotechnologie 2004”, 2004, 88-89
33. Human Brain Proteome Project – Towards an inventory of the brain proteins, Klose J., Meyer H.E., Hamacher M., van Hall A., Marcus K., BioForum Europe, 2004 (1), 28-29
34. Die differentielle Proteomanalyse im Fokus, Stuehler K., Warscheid B., Meyer H.E., Marcus K., BioForum, 2004 (3), 46-48
35. Innovative Forschungsansätze im NGFN Verbund 'The Human Brain Proteome Project HBPP', Marcus K., Hultschig C., Frank R., Herberg F.W., Schuchhardt J., Seitz H., GenomExpress, 2003 (4), 5-9
36. Fallstricke in der Durchführung von Proteomanalysen, Marcus K., Meyer HE., Biospektrum, Sonderausgabe 2003 (9), 492-494

Book co-editor

• Invited Guest Editor, „Quantitative Methods in Proteomics“, Methods in Molecular Biology, Humana Press, published 2012
• Invited Editor, „Proteomics in Drug Research“, Methods and Principles in Medicinal Chemistry, Wiley-VCH, published 2004


Television

„Project Future: Proteomics“, Deutsche Welle, April 11th 2004, Report about the young scientist Dr. Katrin Marcus, Juniorprofessor for Proteomics, in the framework of the Human Brain Proteome Project